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DEFEROXAMINA

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Defroxamine
chemical compound

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Defroxamine, also known as Deferrioxamin, DFO, DFOA and Lateral, is a chelating agent used to promote the removal of excess iron in the body. It binds to blood free of blood so that its excessive amount does not cause harm to organs or tissues. Quelates are eliminated urinaryly. It is administered by intraomuscular injection, vein, or under the skin. [1] It is an isolated product isolated from Pilosus Streptomyces.
Defroxamine
DEFEROXAMINE-2D-SKELETAL.png
Name (IUPAC) systematic
N '-[5- (acetyl-hydroxi-amino) pentil] -n- [5- [3- (5-aminopentil-hydroxy-carbamil) propanilamino] pentil] -n-hydroxy -butane diamide
Identifiers
Cas 70-51-9
ATC V03AC01 code
Pubchem 2973
DRUGBANK DB00746
Chemspider 2867
Chebi 4356
Chemical data
Formula C25H48N6O8
Mole weight. 560.68402 g/mol
Smiles
CC (= O) N (CCCCCNC (= O) CCC (= O) N (CCCCCCC (= O) CCC (= O) N (CCCCCN) O) O) O) O)
Inchi
Inchi = ubqyurcvbfruqt-uhfffaoya-n
Synonyms Latery
Physical data
Embullition P. 140 ° C (284 ° F)
Pharmacokinetics
Plasma enzyme metabolism
Half life 6 hours
Urinary and fecal excretion
Clinical data
Use in breastfeeding there are currently no data or studies.
ADM WAYS.

Administration routes

    Parenteral

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Index

Origeneditar

Defroxamine was isolated in 1960 as iron chelate of Streptomyces pilosus which produces a siderophore named Ferrioxamine B. The quelate is subsequently treated by chemical means to release the free ligand of iron. In this way, ferrioxamine is isolated and the deferoxamine form is purified.
Actions and properties

Defroxamine has a great affinity for the iron ion Fe3+ Iron (Ka = 1031) and a great advantage is that it does not have much affinity for the calcium ion (Ka = 102). There is evidence that enzymes participating in mitochondrial respiration are the main target of acute iron poisoning. [2]

In vitro studies have shown that deferoxamine in the form of a mesilate, removes the iron of the hemosiderin, ferritin and, in less quantity, of transferrin. The iron found in hemoglobin or cytochromes are left intact. [3]
Pharmacokinetics Editar

Defroxamine is absorbed very little after oral administration, so in most cases a parenteral administration is required either intravenous (IV), intramuscular (IM) or subcutaneous (SC). It is mainly metabolized by blood plasma enzymes so that from here, it can be excreted by kidney.
Collateral effects and warning

Defroxamine, despite its effectiveness, can cause allergic reactions that can occur with pruritus, verdugones and anaphylaxis. Other adverse effects include dysuria, abdominal discomfort, diarrhea, fever, leg cramps and tachycardia. Occasional cataract cases have been reported and recorded.

In long -term and dose therapies, in transfusions -dependent talasmia, deferoxamine can cause neurotoxicity. Both visual and auditory changes have been observed and described.
Contraindications Edit

People with renal failure and anuria should avoid the use of the drug. It can be used in pregnant women as long as there is a firm indication. Defroxamine is not recommended in primary hemochromatosis, although it is effective in secondary hemochromatosis or when phlegotomies are not possible. [4]
Indications Edit

In acute iron poisoning, intramuscular administration is preferred unless the patient is in shock. The doses are continued at intervals of 4 - 12 hours according to the clinical response. If the patient is in shock, the intravenous route will be used.

Treatment with this agent is useful in patients with some types of chronic anemias, talasmia and myelodysplastic syndrome, who require multiple blood transfusions by increasing iron levels in the body. In talasyemia the intramuscular route is used. It has been noted that the continuous subcutaneous route is almost as effective as the intravenous pathway.

Defroxamine can also be used to be aluminum in dialysis patients.
Other uses edit

Some authors have focused on the role of deferoxamine as an antioxidant and free radical collector in intoxications different from iron. However, these properties are still not proven. [5]
Interactions Edit

Vitamin C can increase the adverse effects of deferoxamine.
Presentations Edit

Deforexamine is presented in the form of ampoules containing 500 mg of the drug for the application intramuscular, intravenous and subcutaneous.
See also the end

      Wikcionario has definitions and other information about hyperferritine

Rick says-- It was actually LaQUINTAColumna... the 5th Column in Spanish... Here's the main website where orwell.city got their information.

https://www.laquintacolumna.net/

It's possible to translate using an online translator.. .though laborious-- still better than nothing.

https://www.all-translation.com/translation/croatian/to-english/